Cholera toxin and breast cancer: Immunological insights and therapeutic opportunities

Zahra  Keshvari; Raheleh Sheikhi

doi:10.66224/jcbior.7.1.355

Authors

Zahra Keshvari Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Raheleh Sheikhi Department of Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran https://orcid.org/0000-0003-0760-1338

DOI:

https://doi.org/10.66224/jcbior.7.1.355

Keywords:

Vibrio cholerae , Microbial toxin , Breast cancer

Abstract

No abstract.

References

1. Zhang Y, Ji Y, Liu S, Li J, Wu J, Jin Q, et al. Global burden of female breast cancer: new estimates in 2022, temporal trend and future projections up to 2050 based on the latest release from GLOBOCAN. J Natl Cancer Cent. 2025;5(3):287-296.

DOI: 10.1016/j.jncc.2025.02.002 PMID: 40693239

2. Saman H, Makni-Maalej K, El-Ella DMA, Al-Tamimi MY, AbuHaweeleh MN, Abuhayeh N, et al. Immune checkpoint blockade in cancer: current insights and future horizons. Discov Oncol. 2026;17(1):209.

DOI: 10.1007/s12672-025-04361-7 PMID: 41483376

3. George-Chandy A, Eriksson K, Lebens M, Nordström I, Schön E, Holmgren J. Cholera toxin B subunit as a carrier molecule promotes antigen presentation and increases CD40 and CD86 expression on antigen-presenting cells. Infect Immun. 2001;69(9):5716-25.

DOI: 10.1128/IAI.69.9.5716-5725.2001 PMID: 11500448

4. Tepale-Segura A, Gajón JA, Muñoz-Cruz S, Castro-Escamilla O, Bonifaz LC. The cholera toxin B subunit induces trained immunity in dendritic cells and promotes CD8 T cell antitumor immunity. Front Immunol. 2024;15:1362289.

DOI: 10.3389/fimmu.2024.1362289 PMID: 38812523

5. Paul S, Kaya M, Johnsson O, Grauers Wiktorin H, Törnell A, Arabpour M, et al. Targeting murine metastatic cancers with cholera toxin A1-adjuvanted peptide vaccines. Hum Vaccin Immunother. 2025;21(1):2455240.

DOI: 10.1080/21645515.2025.2455240 PMID: 39848921

6. Afaloniati H, Aindelis G, Spyridopoulou K, Lagou MK, Tsingotjidou A, Chlichlia K, et al. Peri-weaning cholera toxin consumption suppresses chemically-induced carcinogenesis in mice. Int J Cancer. 2024;154(6):1097-1110.

DOI: 10.1002/ijc.34816 PMID: 38095490

7. Argyris DG, Markaki MP, Afaloniati H, Karagiannis GS, Poutahidis T, Angelopoulou K. Suppression of chemically induced mammary cancer by early-life oral administration of cholera toxin in mice is associated with aberrant regulation of Bmp and Notch signaling pathways. Mol Biol Rep. 2025;52(1):150.

DOI: 10.1007/s11033-025-10271-2 PMID: 39841292

8. Zheng G, Sundquist J, Sundquist K, Ji J. Association of post-diagnostic use of cholera vaccine with survival outcome in breast cancer patients. Br J Cancer. 2021;124(2):506-512.

DOI: 10.1038/s41416-020-01108-9 PMID: 33024264

9. Kenworthy AK, Schmieder SS, Raghunathan K, Tiwari A, Wang T, Kelly CV, et al. Cholera Toxin as a Probe for Membrane Biology. Toxins (Basel). 2021;13(8):543.

DOI: 10.3390/toxins13080543 PMID: 34437414

10. Kallogjerovic S, Velázquez-Quesada I, Hadap R, Gligorijevic B. Retrograde tracing of breast cancer-associated sensory neurons. J Microsc. 2025;298(2):232-244.

DOI: 10.1111/jmi.13340 PMID: 38881512