Thymoquinone and chemoresistance in non-small cell lung cancer: Preclinical promise or therapeutic potential?

Authors

  • Maryam Alsadat Baniaghil Firouzgar Hospital, Department of Internal Medicine, School Of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Seyedeh Hatameh Asadinejad Tahergourabi Firouzgar Hospital, Department of Internal Medicine, School Of Medicine, Iran University of Medical Sciences, Tehran, Iran https://orcid.org/0009-0008-6790-8685
  • Niloofar Keikhaei Sayad Shirazi Hospital, Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

DOI:

https://doi.org/10.61882/jcbior.6.1.285

Keywords:

Thymoquinone, Nigella sativa, Black cumin, Lung cancer, Chemoresistance

Abstract

No Abstract.

References

1. Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008;83(5):584-94.

DOI: 10.4065/83.5.584 PMID: 18452692

2. Alaufi OM, Noorwali A, Zahran F, Al-Abd AM, Al-Attas S. Cytotoxicity of thymoquinone alone or in combination with cisplatin (CDDP) against oral squamous cell carcinoma in vitro. Sci Rep. 2017;7(1):13131. DOI: 10.1038/s41598-017-13357-5 PMID: 29030590

3. Durga BB, Ramachandran V, Senthil B, Soloman VG, Elshikh MS, Almutairi SM, et al. Unleashing of cytotoxic effects of thymoquinone-bovine serum albumin nanoparticles on A549 lung cancer cells. Open Life Sci. 2024;19(1):20221000.

DOI: 10.1515/biol-2022-1000 PMID: 39655191

4. Yang J, Kuang XR, Lv PT, Yan XX. Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway. Tumour Biol. 2015;36(1):259-69.

DOI: 10.1007/s13277-014-2628-z PMID: 25238880

5. Gurbilek M, Deniz CD, Eroglu Gunes C, Kurar E, Reisli I, Kursunel MA, et al. Anticancer activity of thymoquinone in non-small cell lung cancer and possible involvement of PPAR-γ pathway. Int J Radiat Biol. 2025;101(4):370-381.

DOI: 10.1080/09553002.2025.2449953 PMID: 39946226

6. Jafri SH, Glass J, Shi R, Zhang S, Prince M, Kleiner-Hancock H. Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo. J Exp Clin Cancer Res. 2010;29(1):87. DOI: 10.1186/1756-9966-29-87

PMID: 20594324

7. Gomathinayagam R, Ha JH, Jayaraman M, Song YS, Isidoro C, Dhanasekaran DN. Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets. J Cancer Prev. 2020;25(3):136-151. DOI: 10.15430/JCP.2020.25.3.136

PMID: 33033708

8. Zhang Y, Liu X, Dang W, Liu L. Thymoquinone inhibits lung cancer stem cell properties via triggering YAP degradation. Carcinogenesis. 2023;44(5):426-435.

DOI: 10.1093/carcin/bgad026 PMID: 37105709

9. Ansar FH, Latifah SY, Wan Kamal WHB, Khong KC, Ng Y, Foong JN, et al. Pharmacokinetics and Biodistribution of Thymoquinone-loaded Nanostructured Lipid Carrier After Oral and Intravenous Administration into Rats. Int J Nanomedicine. 2020;15:7703-7717. DOI: 10.2147/IJN.S262395

PMID: 33116496

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Published

2025-03-30

Issue

Section

Letter

How to Cite

Thymoquinone and chemoresistance in non-small cell lung cancer: Preclinical promise or therapeutic potential?. (2025). Journal of Current Biomedical Reports, 6(1), 27-28. https://doi.org/10.61882/jcbior.6.1.285

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